Why the study?
Do different antihypertensive therapies (amlodipine, bisoprolol/HCTZ, enalapril) differentially affect quality of life in hypertensive patients?
Population
218 hypertensive patients with diastolic blood pressure after a 4- to 5-week placebo washout period
Comparison
Amlodipine, bisoprolol/hydrochlorothiazide 6.25… vs Active comparators
Design
RCT, randomized, parallel group, double-blind
Follow-up
12 weeks
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Adverse events should guide antihypertensive selection to preserve quality of life; extends RCT evidence that blood pressure reduction magnitude does not drive patient-reported outcomes.
Do different antihypertensive therapies (amlodipine, bisoprolol/HCTZ, enalapril) differentially affect quality of life in hypertensive patients?
Changes in quality of life during antihypertensive therapy correlate directly with adverse events rather than the degree of blood pressure reduction.
A 1996 study studied this question.
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