July 1, 1998AJP Heart and Circulatory Physiology

5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog

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Why the study?

Does 5,6-EET reduce pulmonary vascular resistance in isolated canine lungs?

Structured PICO

Does 5,6-EET reduce pulmonary vascular resistance in isolated canine lungs?

Population

Isolated canine lungs perfused with physiological salt solution and canine intrapulmonary vessels

Intervention

5,6-Epoxyeicosatrienoic acid (5,6-EET) 10(-5) M administered into the perfusate

Comparator

Constrictor agents (U-46619 or 5-hydroxytryptamine) alone, and in the presence of indomethacin (10(-4) M)

Outcome

Pulmonary vascular resistance (PVR) and segmental resistancesurrogate

5,6-EET acts as a cyclooxygenase-dependent vasodilator in the intact pulmonary circulation, with its effects varying by the constrictor agent and vascular segment.

Authors

ASAlan H. StephensonSaint Louis University RSRandy S. SpragueUCLouvain Saint-Louis Brussels ALAndrew J. LonigroUnited States Department of Veterans Affairs

Discussion

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Implication

5,6-EET attenuates vasoconstriction in isolated canine lungs; hypothesis-generating for EET-based pulmonary therapies with no clinical implications yet.

Cite This Study

Stephenson et al. (1998) studied this question.

synapsesocial.com/papers/6a8ced107f6edfa4d030582c https://doi.org/10.1152/ajpheart.1998.275.1.h100

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Implication

5,6-EET attenuates vasoconstriction in isolated canine lungs; hypothesis-generating for EET-based pulmonary therapies with no clinical implications yet.

5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog

Structured PICO

Discussion

Implication

Cite This Study

5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider