Why the study?
Does the ACE gene I/D polymorphism associate with left ventricular hypertrophy, BMI, and lipid profiles in elderly patients with coronary heart disease?
Does the ACE gene I/D polymorphism associate with left ventricular hypertrophy, BMI, and lipid profiles in elderly patients with coronary heart disease?
In elderly patients with CHD in the Far North, the ACE*I/*I genotype frequency decreases with age and is associated with left ventricular hypertrophy, while the ACE*D/*I genotype is associated with higher BMI and lipid levels.
ACE I/D variants associate with LVH and metabolic traits in elderly northern CHD; leaves open causal effects on longevity or hypertrophy.
The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of age there is a decrease in the frequency of the genotype ACE*I/*I and a tendency of increase in the frequency of the genotype ACE*D/*D. A comparative analysis of genotypes АСЕ*D/*D and АСЕ*D/*I has showed sex differences in the frequency of homozygous genotype detection. Left ventricular hypertrophy can be observed significantly more often among carriers of genotype ACE*I/*I established by Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.
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Arkhipova et al. (2014) studied this question.
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