Association of polymorphism of angiotensin-converting enzyme gene I/D and D442G cholesterol ester transfer protein gene with risk factors for atherosclerosis among elderly and senile patients with coronary heart disease in the republic of Sakha (Yakutia)

A comparative analysis was performed for frequency distribution of I/D polymorphism of angiotensin-converting enzyme ( ACE ) gene and D 442 G polymorphism of cholesterol ester transfer protein ( CETP ) gene in elderly and senile patients and long-lived patients with CHD with regard to ethnicity, age, and gender. The frequency of ACE * I /* I genotype reduces with age; the tendency towards increased proportion of ACE * D /* D genotype was observed. During the comparative analysis of ACE * D /* D and ACE * D /* I genotypes, gender differences were found in frequency of homozygous ACE * D /* D genotype. The carriers of ACE * D/D genotype were identified significantly more often among men than among women. Among all patients and especially among Yakuts, left ventricular hypertrophy confirmed by Sokolov-Lyon index for ECG was observed significantly more often in carriers of ACE * I /* I genotype. During the study of D 442 G polymorphism of CETP gene, the carriers of CETP * D /* G genotype were identified significantly more often among Yakuts than among nonindigenous individuals. During the comparison of frequencies of I/D polymorphism of the ACE gene, significant differences were observed with respect to body mass index (BMI) and blood lipids. In comparison of CETP * D /* D and CETP * D /* G genotypes, no significant association with CHD risk factor was found.