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September 1, 1982Journal of Cardiovascular Pharmacology

Comparison of Papaverine and Verapamil on Frequency-Dependent Changes in max of K-Depolarized Ventricular Tissue

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Population

K-depolarized guinea pig ventricular strips

Comparison

Papaverine (10 M), verapamil (10 M), Ba2+, or… vs Ba2+-treated condition or comparison between…

Design

Preclinical

Authors

MSMichael C. SanguinettiElectrophysiologyTWTheodore C. WestUniversité Bordeaux Montaigne

Discussion

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Implication

Does not support papaverine as verapamil-like Ca antagonist in ventricular tissue; leaves open its mechanism and clinical relevance.

Structured PICO

P
Population
K-depolarized guinea pig ventricular strips
I
Intervention
Papaverine (10(-5) M), verapamil (10(-7) M), Ba2+ (0.2 mM, 0.8 mM), or isoproterenol (5 x 10(-7) M)
C
Comparator
Ba2+-treated condition (for verapamil) or comparison between agents
O
Outcome
Frequency-dependent changes in maximum upstroke velocity (Vmax) to indirectly measure slow inward current (Isi)surrogate

Papaverine does not exhibit calcium antagonist properties similar to verapamil in K-depolarized ventricular tissue.

Cite This Study

Sanguinetti et al. (1982) studied this question.

synapsesocial.com/papers/6a8cffdf7bbddcec12968089https://doi.org/10.1097/00005344-198209000-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Frequency-Dependent Effects of Adenosine and Verapamil on Atrioventricular Conduction of Isolated Guinea Pig Hearts1993 · 12 citations
  2. 2Tonic and Frequency-Dependent Vmax Block Induced by Imipramine in Guinea Pig Ventricular Muscle Fibers1990 · 17 citations
  3. 3Modification of "depressed fast channel dependent slow conduction" by lidocaine and verapamil in the presence or absence of catecholamines. Evidence for alteration of preferential ionic channels for slow conduction.1983 · 9 citations
  4. 4Frequency- and Voltage-Dependent Effects of Aprindine on the Upstroke Velocity of Action Potential in Guinea Pig Ventricular Muscles1987 · 18 citations
  5. 5Effects of verapamil on ischemia-induced changes in extracellular K+, pH, and local activation in the pig.1986 · 39 citations