Two patients taking procainamide developed agranulocytosis with septicaemia. Both recovered from the agranulocytosis, but one died of haemorrhagic pancreatitis and anuria. The latter had a strongly positive antinuclear antibody (A.N.A.) test. The frequency and relationship of the agranulocytosis and the lupoid syndrome caused by procainamide are briefly discussed. Precautionary measures for the early recognition of this grave hazard in exposed patients are advocated.
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Hickson et al. (1972) studied this question.
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