Population
Long S-2 fragment (100,000 daltons) isolated from myosin
Design
Preclinical
Authors
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Rapid myosin S-2 flexibility may influence crossbridge cycling; leaves open relevance to human cardiac muscle.
The S-2 region of myosin can undergo rapid helix-coil transitions in a time range approximating the cycle time of a crossbridge, suggesting significant flexibility at physiological temperatures.
Tsong et al. (1979) studied this question.
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