Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function
Why the study?
Does remikiren improve blood pressure and renal hemodynamics in hypertensive patients with normal or impaired renal function?
Population
14 hypertensive patients with normal or impaired renal function
Design
Cohort, single-blind
Follow-up
8 days
Authors
Discussion
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Member takes
Implication
May support short-term proteinuria reduction in hypertension; leaves open long-term renoprotection pending randomized trials.
Structured PICO
Does remikiren improve blood pressure and renal hemodynamics in hypertensive patients with normal or impaired renal function?
P
Population
14 hypertensive patients with normal or impaired renal function
I
Intervention
Remikiren 600 mg once daily for 8 days
O
Outcome
Blood pressure, renal haemodynamics, and proteinuriasurrogate
Short-term treatment with the renin inhibitor remikiren lowers blood pressure and reduces proteinuria in hypertensive patients, suggesting renoprotective potential.
Cite This Study
Paassen et al. (2000) studied this question.