Key result
Remikiren dose-dependently reduced plasma renin activity, but only the 1,000 mg dose significantly reduced erect blood pressure (from 114/65 to 96/50) in salt-depleted men.
Why the study?
Does oral remikiren reduce blood pressure and inhibit renin activity in salt-depleted normal men?
Population
12 normal men, mean age 28 ± 9 years, weight 77 ± 10 kg, with renin-angiotensin system activated by salt…
Comparison
Remikiren at single doses of 30, 100, 300, 600… vs Matching placebo.
Design
RCT, randomised 2 weeks apart, double-blind
Authors
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Remikiren requires impractically high doses for blood pressure reduction despite renin inhibition; extends pharmacokinetic limits of early oral renin inhibitors.
RCT (n=12)
Double-blind
randomised
Does oral remikiren reduce blood pressure and inhibit renin activity in salt-depleted normal men?
Oral remikiren effectively inhibits plasma renin activity but has minimal hemodynamic effects, requiring very high doses to lower blood pressure even in salt-depleted subjects.
MacFadyen et al. (1995) conducted an RCT in Healthy volunteers (salt-depleted) (n=12). Remikiren (Ro 42-5892) vs. Placebo was evaluated on Plasma renin activity, active renin, and blood pressure. Remikiren dose-dependently reduced plasma renin activity, but only the 1,000 mg dose significantly reduced erect blood pressure (from 114/65 to 96/50) in salt-depleted men.
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