January 1, 1996Xenobiotica

Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates

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Population

rat, dog and various species of primate (including bile-duct cannulated rat and dog)

Design

Preclinical

Authors

PCPh. CoassoloRoche (Switzerland)WFWalter FischliActelion (Switzerland)JCJ-P. ClozelRoche (Switzerland)

Discussion

Member takes

Implication

Rapid absorption despite low bioavailability in animals should not guide clinical use; leaves open tissue compartment mediation for further study.

Structured PICO

Population

rat, dog and various species of primate (including bile-duct cannulated rat and dog)

Intervention

remikiren (intravenous and oral administration)

Outcome

pharmacokinetics (mean residence time, plasma clearance, oral bioavailability, absorption)surrogate

Remikiren exhibits rapid absorption but low oral bioavailability and high clearance across species, suggesting its prolonged blood pressure lowering effect may be mediated through a tissue compartment.

Cite This Study

Coassolo et al. (1996) studied this question.

synapsesocial.com/papers/6a8d1770851ec846c20e572f https://doi.org/10.3109/00498259609046712

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Implication

Rapid absorption despite low bioavailability in animals should not guide clinical use; leaves open tissue compartment mediation for further study.

Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider