Key result
Remikiren monotherapy did not significantly reduce blood pressure in essential hypertension, but adding hydrochlorothiazide produced a marked reduction in blood pressure.
Why the study?
Does remikiren alone or in combination with hydrochlorothiazide reduce blood pressure in patients with essential hypertension?
Population
29 patients with essential hypertension
Comparison
Remikiren 600 mg orally for 8 days, with… vs Remikiren 600 mg orally for 8 days, with placebo…
Design
RCT, Single-blind placebo run-in, double-blind for the add-on phase
Follow-up
8 days
Authors
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Remikiren monotherapy lacks efficacy in essential hypertension; challenges renin inhibitor monotherapy and supports diuretic combination.
RCT (n=29)
Double-blind
Does remikiren alone or in combination with hydrochlorothiazide reduce blood pressure in patients with essential hypertension?
Short-term administration of the oral renin inhibitor remikiren does not significantly lower blood pressure as monotherapy but has a marked antihypertensive effect when combined with a diuretic.
Anders Himmelmänn (1996) conducted an RCT in Essential hypertension (n=29). Remikiren (with or without hydrochlorothiazide) vs. Placebo was evaluated on Blood pressure. Remikiren monotherapy did not significantly reduce blood pressure in essential hypertension, but adding hydrochlorothiazide produced a marked reduction in blood pressure.
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