Why the study?
Do endogenous ouabain levels and alpha-adducin polymorphisms interact to affect renal sodium handling and blood pressure response to volume loading in untreated hypertensive patients?
Population
155 untreated hypertensive patients
Comparison
Volume loading (saline loading) vs Comparisons made between subgroups based on…
Design
Cohort
Authors
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May stratify salt sensitivity via ADD1 genotyping in hypertension; leaves open whether this guides volume management.
Do endogenous ouabain levels and alpha-adducin polymorphisms interact to affect renal sodium handling and blood pressure response to volume loading in untreated hypertensive patients?
In untreated hypertensive patients, the ADD1 Trp allele and high endogenous ouabain levels interact to increase salt sensitivity and alter renal sodium handling during volume expansion.
Manunta et al. (2008) studied this question.
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