Why the study?
Is the alpha-adducin Gly460Trp genotype associated with altered erythrocyte sodium transport rates and blood pressure response to diuretics in primary hypertensives?
Population
268 never-treated primary hypertensives from North Sardinia
Comparison
Presence of one or two alpha-adducin 460Trp… vs Absence of the 460Trp allele (implied wild-type)
Design
Cohort
Authors
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May explain variable diuretic responses; leaves open whether genotyping should guide therapy.
Is the alpha-adducin Gly460Trp genotype associated with altered erythrocyte sodium transport rates and blood pressure response to diuretics in primary hypertensives?
The Gly460Trp alpha-adducin polymorphism is associated with altered cellular sodium transport and may partly explain the variability in blood pressure response to diuretics in primary hypertensive patients.
Glorioso et al. (2002) studied this question.
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