Why the study?
Does the sympathetic response to an oral glucose load differ between hypertensive and normotensive subjects?
Does the sympathetic response to an oral glucose load differ between hypertensive and normotensive subjects?
Hypertensive subjects demonstrate a defective sympathetic activation in response to glucose loading, characterized by a blunted norepinephrine response and a drop in blood pressure.
May predispose hypertensives to postprandial hypotension; hypothesis-generating for sympathetic defects and requires prospective confirmation.
Blood pressure, plasma norepinephrine (NE) and epinephrine (E) levels in responses to oral glucose load (OGTT) and to head-up tilting (Tilt) were measured in 14 hypertensive (HT) and 17 normotensive subjects (NT). In response to OGTT, NE significantly increased within 30 minutes (+25 +/- 8%; p less than 0.05) in NT, followed by a decline to the basal level, while it remained unchanged in HT (+5 +/- 8%). E decreased similarly during OGTT in both groups. Mean blood pressure, however, fell only in HT (-3.3 +/- 1.1%; p less than 0.05) but did not change in NT. Blood pressure, NE and E responses to Tilt did not differ between NT and HT. These results suggest that hypertensive subjects have some defects in sympathetic activation in response to glucose loading.
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Tomita et al. (1989) studied this question.
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