Population
Rabbit portal vein smooth muscle cells
Comparison
Micromolar concentrations of external calcium ions vs < 10 nM Ca2+o
Design
Preclinical
Authors
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No immediate implications for clinical vascular management; extends mechanistic understanding of Ca2+ effects on cation channels in animal models.
External calcium ions facilitate the noradrenaline-evoked cation current in rabbit portal vein smooth muscle cells by altering channel kinetics and conductance.
Helliwell et al. (1998) studied this question.
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