Population
6-week-old normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Infusion for 4 days with 2 mg/kg/day… vs Saline infusion in WKY and SHR
Design
Preclinical
Follow-up
4 days
Authors
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Hypothesis-generating for angiotensin II-mediated vascular remodeling; leaves open translation to human hypertension.
In young rats, angiotensin II induces small artery hypertrophy independently of blood pressure, whereas chronic alpha-1 adrenergic stimulation reduces contractile reactivity without structural changes.
Boonen et al. (1993) studied this question.
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