Population
Male Wistar rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Differential AII responses by innervation density are hypothesis-generating in rodents; leaves open perivascular nerve targeting in human hypertension.
Angiotensin II induces hypertrophy and hyperreactivity in densely innervated mesenteric arteries but not sparsely innervated epigastric arteries, suggesting a role for perivascular nerves.
Stassen et al. (2008) studied this question.
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