Why the study?
Does Goldblatt-induced hypertension increase mean circulatory pressure in dogs?
Does Goldblatt-induced hypertension increase mean circulatory pressure in dogs?
The induction of hypertension via the Goldblatt technique in dogs leads to a significant increase in mean circulatory pressure.
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Elevates mean circulatory pressure in canine Goldblatt hypertension; leaves open translation to human disease.
Ten dogs were made hypertensive by the Goldblatt technique. The mean arterial pressure increased from an average control value of 117 mm Hg up to 161 mm Hg. After the animals had become hypertensive, the mean circulatory pressures were measured. These averaged 9.03 (±0.31 SEM) mm Hg, compared with measurements of mean circulatory pressure in ten normal dogs which averaged 7.0 (±0.17 SEM) mm Hg. The increase in mean circulatory pressure was highly significant ( t = 5.75).
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Richardson et al. (1964) studied this question.
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