Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 22, 2003CirculationOpen Access

Inhibitory Cardiac Transcription Factor, SRF-N, Is Generated by Caspase 3 Cleavage in Human Heart Failure and Attenuated by Ventricular Unloading

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does ventricular unloading with an LVAD attenuate caspase 3-mediated cleavage of SRF in patients with end-stage heart failure?

Population

Cardiac samples from 13 patients with end-stage heart failure at the time of transplantation, 7 normal…

Comparison

Ventricular unloading via left ventricular… vs Normal hearts and end-stage failing hearts…

Design

Preclinical

Authors

JCJiang ChangPrecision for Medicine (United States)WLWei LeiXijing HospitalTOTakayuki OtaniHouston Methodist

Discussion

Loading...

Member takes

Overview

LVAD unloading may attenuate SRF cleavage in failing hearts; hypothesis-generating for human studies.

Structured PICO

Does ventricular unloading with an LVAD attenuate caspase 3-mediated cleavage of SRF in patients with end-stage heart failure?

P
Population
Cardiac samples from 13 patients with end-stage heart failure at the time of transplantation, 7 normal hearts, and 10 patients with left ventricular assist devices (LVAD), as well as myogenic cells for in vitro experiments.
I
Intervention
Ventricular unloading via left ventricular assist device (LVAD)
C
Comparator
Normal hearts and end-stage failing hearts without LVAD
O
Outcome
SRF protein levels and fragmentation (cleavage by caspase 3)surrogate

Caspase 3 activation in heart failure generates a dominant-negative transcription factor by cleaving SRF, a process that may be reversed by ventricular unloading with an LVAD.

Cite This Study

Chang et al. (2003) studied this question.

synapsesocial.com/papers/6a8d1dfc2261ca2436cf89d2https://doi.org/10.1161/01.cir.0000084502.02147.83
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor2001 · 149 citations
  2. 2Serum Response Factor Cleavage by Caspases 3 and 7 Linked to Apoptosis in Human BJAB Cells2001 · 28 citations
  3. 3Apoptosis in Myocytes in End-Stage Heart Failure1996 · 1,449 citations
  4. 4Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure2002 · 228 citations
  5. 5Different Signaling Pathways Induce Apoptosis in Endothelial Cells and Cardiac Myocytes During Ischemia/Reperfusion Injury2002 · 169 citations