Why the study?
Does mild to moderate hypertension with or without LVH alter Doppler-derived indices of left ventricular diastolic filling in elderly patients compared to normotensive controls?
Does mild to moderate hypertension with or without LVH alter Doppler-derived indices of left ventricular diastolic filling in elderly patients compared to normotensive controls?
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In elderly patients, mild to moderate hypertension with or without LVH does not significantly alter Doppler-derived indices of left ventricular diastolic filling compared to age-matched normotensive controls, indicating that aging itself is the primary driver of these changes.
OBJECTIVE: To evaluate the effects of mild to moderate hypertension and of LVH on diastolic filling and other Doppler indices in the elderly. DESIGN: Survey with a control group. SUBJECTS: Seventy-one hypertensives (34 men, 37 women) referred for echocardiograms and 32 age- and sex-matched normotensive volunteers. Thirty-six of the hypertensives had LVH; 34 did not. SETTING: Echocardiographic laboratory. MEASUREMENTS: M-mode, two-dimensional, and pulsed Doppler echocardiograms. A wide variety of Doppler-derived indices of diastolic function were assessed. RESULTS: All Doppler derived indices of left ventricular diastolic filling (peak E, peak A, their ratio, EF slope, time-velocity integrals, atrial filling fraction, and isovolumic relaxation time) were similar among the three groups. CONCLUSION: Elderly mild to moderate hypertensives with or without LVH have LV diastolic filling that is normal for age. The identification of pathological diastolic dysfunction requires comparison to age-matched controls, since aging, a major factor influencing diastolic filling, can mask the effect of hypertension.
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Nicolino et al. (1993) studied this question.
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