Why the study?
Does mechanical stretch of the aortic wall increase blood pressure and heart rate in conscious dogs?
Population
Conscious dogs with a previously implanted cannula covered by an inflatable rubber balloon in the descending…
Comparison
Mechanical activation of aortic sympathetic… vs Control values (baseline before stretch)
Design
Preclinical
Authors
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Supports positive feedback sympathetic reflexes from aortic stretch in conscious dogs; leaves open translation to human baroreflex function or hypertension.
Does mechanical stretch of the aortic wall increase blood pressure and heart rate in conscious dogs?
Mechanical stretch of the aorta in conscious dogs elicits a sympathetic pressor reflex, increasing blood pressure and heart rate, indicating positive feedback sympathetic reflexes are operative.
Pagani et al. (1979) studied this question.
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