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July 27, 2020Angiology

NLR was a significant predictor of mortality in patients with MINOCA (HR: 1.24, 95% CI: 1.09-1.41, P = .001).

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Why the study?

MINOCA is a heterogeneous entity with an inflammatory etiopathogenesis, but the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in these patients remained to be investigated.

Does the neutrophil-to-lymphocyte ratio predict mortality in patients with myocardial infarction with non-obstructive coronary arteries?

Population

72 patients with MINOCA and 248 controls with normal coronary angiograms

Comparison

Patients with MINOCA vs controls with normal coronary angiograms

Design

Retrospective observational study

Follow-up

Median 21 (max: 42) months

Authors

AGAhmet GürdalKKKudret KeskinSSSerhat Sığırcı

Discussion

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Overview

The neutrophil-to-lymphocyte ratio is elevated in MINOCA patients compared to controls and serves as a significant predictor of long-term mortality.

Structured PICO

Does the neutrophil-to-lymphocyte ratio predict mortality in patients with myocardial infarction with non-obstructive coronary arteries?

P
Population
320 subjects including 72 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and 248 controls with normal coronary angiograms, mean age 46 ± 9 years, 55% female.
I
Intervention
Neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker
C
Comparator
Controls with normal coronary angiograms
O
Outcome
Mortality at median 21 months follow-uphard clinical

The neutrophil-to-lymphocyte ratio is elevated in MINOCA patients compared to controls and serves as a significant predictor of long-term mortality.

Cite This Study

Gürdal et al. (2020) studied this question.

synapsesocial.com/papers/6a8ea65690e8ec90ff28e0c5https://doi.org/10.1177/0003319720938621
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of neutrophil-to-lymphocyte ratio and monocyte-tolymphocyte ratio with all-cause mortality in patients with ischemia and non-obstructive coronary arteries2025
  2. 2Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients2024 · 2 citations
  3. 3Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries2019 · 158 citations
  4. 4The prognostic value of neutrophil-to-lymphocyte ratio across all stages of coronary artery disease2021 · 53 citations
  5. 5Predictive Value of Neutrophil-to-Lymphocyte Ratio in Patients with Acute Myocardial Infarction in Coronary Angiographic Profile and Left Ventricular Ejection Fraction in North Indian Population2025