Key result
Although canine cTnI values from Biosite, Stratus, and Access analyzers are closely correlated (r=0.61 to 0.89 in clinical samples), wide limits of agreement mean they cannot be directly compared.
Why the study?
Are canine cardiac troponin I concentrations comparable when measured by three different commercial analyzers?
Population
23 dogs with cardiac disease and reconstituted purified canine free cTnI diluted with canine plasma
Design
Preclinical
Authors
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Clinicians must interpret canine cTnI with assay-specific caution; leaves open standardization of veterinary troponin assays.
Observational (n=23)
Are canine cardiac troponin I concentrations comparable when measured by three different commercial analyzers?
Effect estimate: r=0.61 to 0.89
Canine cardiac troponin I values obtained from different commercial analyzers are highly correlated but cannot be directly compared due to wide limits of agreement.
Adin et al. (2006) conducted an observational in Cardiac disease (n=23). Biosite Triage Meter, Dade-Behring Stratus, and Beckman-Coulter Access AccuTnI analyzers vs. Each other was evaluated on Correlation of canine plasma cTnI concentrations across 3 analyzers (r=0.61 to 0.89). Although canine cTnI values from Biosite, Stratus, and Access analyzers are closely correlated (r=0.61 to 0.89 in clinical samples), wide limits of agreement mean they cannot be directly compared.
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