Key result
Atrial natriuretic factor infusion decreased whole-body net capillary absorption in anephric rats compared to vehicle (4.8 vs 5.9 ml/kg, P<0.05).
Why the study?
Does atrial natriuretic factor decrease whole-body capillary absorption in rats compared to vehicle or furosemide?
Population
Anesthetized rats (including anephric rats)
Comparison
Atrial natriuretic factor infusion for 75 min vs Vehicle only, and furosemide
Design
Preclinical
Follow-up
75 min
Authors
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ANF effects on capillary absorption in anephric models require caution before human extrapolation; leaves open clinical relevance in volume regulation.
Does atrial natriuretic factor decrease whole-body capillary absorption in rats compared to vehicle or furosemide?
Absolute Event Rate: 4.8% vs 5.9%
p-value: p=<0.05
ANF decreases whole-body capillary absorption in rats by increasing average capillary hydrostatic pressure, unlike furosemide which allows sufficient capillary absorption to maintain plasma volume.
Trippodo et al. (1987) studied this question. Atrial natriuretic factor (ANF) vs. Vehicle only and furosemide was evaluated on Whole-body net capillary absorption (ml/kg) (p=<0.05). Atrial natriuretic factor infusion decreased whole-body net capillary absorption in anephric rats compared to vehicle (4.8 vs 5.9 ml/kg, P<0.05).