Key result
Vagal stimulation at 7 Hz totally inhibits the plaice heart beat while 2-3 Hz accelerates it, with both effects being cholinergically mediated and blocked by atropine.
Population
Plaice (Pleuronectes platessa) heart, isolated and in situ
Design
Preclinical
Authors
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Hypothesis-generating for cholinergic rebound excitation in fish heart; leaves open relevance to mammalian autonomic control.
In the plaice heart, both inhibitory and excitatory responses to vagal stimulation are cholinergically mediated, with excitation resulting from rebound following inhibitory hyperpolarization.
Cobb et al. (1973) studied this question. Vagal stimulation and pharmacological agents was evaluated on Heart rate and electrophysiological responses. Vagal stimulation at 7 Hz totally inhibits the plaice heart beat while 2-3 Hz accelerates it, with both effects being cholinergically mediated and blocked by atropine.
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