Key result
Rapid ventricular pacing-induced congestive heart failure in dogs resulted in a significantly lower myocardial energy charge (0.63 vs 0.82, P<0.05) compared to sham-operated controls.
Why the study?
Does rapid ventricular pacing-induced congestive heart failure alter myocardial energy status in a canine model?
Does rapid ventricular pacing-induced congestive heart failure alter myocardial energy status in a canine model?
Absolute Event Rate: 0.63% vs 0.82%
p-value: p=< 0.05
In a canine model of pacing-induced heart failure, myocardial energy charge is significantly reduced without evidence of subendocardial ischemia, suggesting a non-vascular origin for this CHF model.
No takes yet. Share an insight, caveat, or question.
Alerts to metabolic impairment in experimental HF models; leaves open relevance to human disease mechanisms or therapy.
Montgomery et al. (1992) studied Congestive heart failure. Rapid ventricular pacing (RVP) vs. Sham-operated controls was evaluated on Myocardial energy charge (EC) (p=< 0.05). Rapid ventricular pacing-induced congestive heart failure in dogs resulted in a significantly lower myocardial energy charge (0.63 vs 0.82, P<0.05) compared to sham-operated controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: