Key result
Elevation of intrasinusal pressure in dogs induced a distinct decrease in cardiac output, primarily due to the inhibition of sympathetic inotropic discharge to the heart.
Why the study?
Does elevation of intrasinusal pressure decrease cardiac output in dogs?
Population
20 mongrel dogs of either sex, average weight 10 kg, anesthetized with alpha chloralose and urethane.
Comparison
Elevation of intrasinusal pressure and… vs Baseline state before pressure elevation or…
Design
Preclinical
Authors
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May inform canine baroreflex physiology; leaves open translation to human cardiovascular regulation.
Does elevation of intrasinusal pressure decrease cardiac output in dogs?
Elevation of intrasinusal pressure in dogs causes a distinct decrease in cardiac output, primarily due to inhibition of sympathetic inotropic discharge to the heart.
Kumada et al. (1965) studied Healthy (animal model for carotid sinus reflex) (n=20). Elevation of intrasinusal pressure vs. Baseline intrasinusal pressure was evaluated on Change in cardiac output. Elevation of intrasinusal pressure in dogs induced a distinct decrease in cardiac output, primarily due to the inhibition of sympathetic inotropic discharge to the heart.
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