Key result
Nitrous oxide anesthesia during elective abdominal hysterectomy caused a statistically significant 10.3-hour delay in the time to pass feces compared to air (P=0.04).
Why the study?
Does nitrous oxide delay the recovery of bowel function in patients undergoing elective abdominal hysterectomy?
Population
36 patients anaesthetised for elective abdominal hysterectomy with or without salpingo-oophorectomy
Comparison
Isoflurane in nitrous oxide and 30% oxygen vs Isoflurane in air and 30% oxygen
Design
RCT, Randomly assigned
Follow-up
Until recovery of bowel function
Authors
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May warrant avoiding nitrous oxide in abdominal hysterectomy; extends RCT evidence on its adverse GI recovery effects.
RCT (n=36)
Randomized
Does nitrous oxide delay the recovery of bowel function in patients undergoing elective abdominal hysterectomy?
Mean Difference: 10.3
p-value: p=0.04
The use of nitrous oxide during elective abdominal hysterectomy may delay the recovery of bowel function, specifically the passing of faeces.
Pedersen et al. (1993) conducted an RCT in Elective abdominal hysterectomy (n=36). Nitrous oxide vs. Air with 30% oxygen and isoflurane was evaluated on Time elapsing before passing of faeces (10.3 h delay, p=0.04). Nitrous oxide anesthesia during elective abdominal hysterectomy caused a statistically significant 10.3-hour delay in the time to pass feces compared to air (P=0.04).
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