Key result
Amidation, acid-activated omeprazole, and arachidonic acid increased Cl- currents in human lung epithelial cell lines and buccal cells from healthy individuals and cystic fibrosis patients.
Population
Human recombinant ClC-2 Cl- channels expressed in HEK-293 cells, human lung epithelial cell lines, and…
Design
Preclinical
Authors
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Does not alter cystic fibrosis care; leaves open ClC-2 activation as a hypothesis-generating therapeutic target.
ClC-2 Cl- channels are present in human lung epithelia and can be activated by specific agents, highlighting their potential as a therapeutic target for cystic fibrosis.
Cuppoletti et al. (2001) studied Cystic fibrosis. Amidation, acid-activated omeprazole, and arachidonic acid was evaluated on Cl- currents. Amidation, acid-activated omeprazole, and arachidonic acid increased Cl- currents in human lung epithelial cell lines and buccal cells from healthy individuals and cystic fibrosis patients.
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