Key result
Plasma BNP concentrations were significantly higher in the acute phase of Kawasaki disease compared to viral infections (55.0 vs 6.8 pg/mL; P<0.0001) and decreased during the convalescent phase.
Observational (n=62)
Absolute Event Rate: 55% vs 6.8%
p-value: p=<0.0001
Plasma BNP concentrations are significantly elevated in the acute phase of Kawasaki disease and may serve as a useful biological marker for cardiovascular manifestations.
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BNP elevation may aid differentiation of acute Kawasaki disease from viral illness; this Level 3 cohort finding leaves open prospective validation for diagnostic use.
Kawamura et al. (2000) conducted an observational in Kawasaki disease (n=62). Acute Kawasaki disease vs. Viral infection was evaluated on Mean plasma BNP concentration (pg/mL) (p=<0.0001). Plasma BNP concentrations were significantly higher in the acute phase of Kawasaki disease compared to viral infections (55.0 vs 6.8 pg/mL; P<0.0001) and decreased during the convalescent phase.
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