Key result
Brain natriuretic peptide > 50 pg/ml in the acute phase of Kawasaki disease was associated with a higher frequency of abnormal electrocardiograms compared to levels < 50 pg/ml (OR 32.4, p<0.0001).
Why the study?
Can plasma brain natriuretic peptide serve as a useful biochemical marker for myocarditis in patients with Kawasaki disease?
Observational (n=69)
Can plasma brain natriuretic peptide serve as a useful biochemical marker for myocarditis in patients with Kawasaki disease?
Odds Ratio: 32.4
Absolute Event Rate: 72.4% vs 7.5%
p-value: p=<0.0001
Plasma BNP concentration > 50 pg/ml in the acute phase of Kawasaki disease is strongly associated with abnormal ECG findings indicative of myocarditis.
No takes yet. Share an insight, caveat, or question.
May support BNP as myocarditis marker in Kawasaki disease; hypothesis-generating and should not change practice without prospective validation.
Kawamura et al. (2002) conducted an observational in Kawasaki disease (n=69). Brain natriuretic peptide > 50 pg/ml vs. Brain natriuretic peptide < 50 pg/ml was evaluated on Abnormal electrocardiograms (OR 32.4, p=<0.0001). Brain natriuretic peptide > 50 pg/ml in the acute phase of Kawasaki disease was associated with a higher frequency of abnormal electrocardiograms compared to levels < 50 pg/ml (OR 32.4, p<0.0001).
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