Key result
Ventricular septal defect was associated with altered acute phase proteins compared to controls, including lower haptoglobin (0.4 vs 0.6 mg/mL; p=0.016) and higher orosomucoid 2 (p<0.001).
Why the study?
Are plasma acute phase proteins altered in patients with congenital ventricular septal defect compared to normal controls?
Case-Control (n=125)
Are plasma acute phase proteins altered in patients with congenital ventricular septal defect compared to normal controls?
Absolute Event Rate: 0.4% vs 0.6%
p-value: p=0.016
Patients with congenital ventricular septal defect exhibit altered levels of acute phase proteins, which may serve as biomarkers for innate immune system function and reflect underlying inflammation.
May indicate inflammation in congenital VSD; leaves open biomarker utility pending prospective validation.
PURPOSE: Ventricular septal defect (VSD) has intracardiac left-to-right shunt and increased pulmonary flow that may affect the acute phase response (APR). We examined the hypothesis that plasma proteins of VSD patients may be altered. EXPERIMENTAL DESIGN: 2DE and MS were used to detect differential plasma proteins in VSD patients (n = 55) and controls (n = 70). Candidate APR proteins were confirmed by ELISA in new samples. RESULTS: Among three differentially expressed APR proteins from 322 protein spots detected, haptoglobin (0.4 ± 0.04 versus 0.6 ± 0.07 mg/mL; p = 0.016) and serum amyloid P-component (SAP) (3.8 ± 0.2 versus 6.3 ± 0.8 ng/mL; p = 0.003) were significantly lower and orosomucoid 2 (3.1 ± 0.1 mg/mL versus 2.3 ± 0.1 mg/mL; p < 0.001) was significantly higher in VSD patients than in normal controls. CONCLUSIONS AND CLINICAL RELEVANCE: The plasma concentration of three acute phase proteins, haptoglobin, SAP, and orosomucoid 2 are altered that may reflect inflammation, be associated with decreased innate immune system function, and predispose the VSD patients to vulnerability to infections and pulmonary disease. These three proteins in plasma may also be developed as biomarkers for the function of innate immune system in patients with congenital heart disease.
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Zhang et al. (2015) conducted a case-control in Congenital ventricular septal defect (n=125). Ventricular septal defect vs. Normal controls was evaluated on Plasma concentration of haptoglobin (p=0.016). Ventricular septal defect was associated with altered acute phase proteins compared to controls, including lower haptoglobin (0.4 vs 0.6 mg/mL; p=0.016) and higher orosomucoid 2 (p<0.001).
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