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August 1, 1991Anesthesia & Analgesia

Does Desflurane Modify Circulatory Responses to Stimulation in Humans?

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Why the study?

Does desflurane with or without nitrous oxide modify circulatory responses to electrical stimulation in healthy humans?

Population

6 healthy male volunteers

Comparison

Desflurane with or without nitrous oxide at… vs Baseline values before stimulation (control)

Design

Other

Follow-up

6 minutes post-stimulation

Authors

NYNobuhiko YasudaJikei University School of MedicineRWRichard WeiskopfUniversität InnsbruckMCMichael K. CahalanJikei University School of Medicine

Discussion

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Implication

Lower desflurane doses may enhance cardiovascular responses to stimulation; leaves open optimal MAC for attenuation in practice and trials.

Structured PICO

Does desflurane with or without nitrous oxide modify circulatory responses to electrical stimulation in healthy humans?

P
Population
6 healthy male volunteers
I
Intervention
Desflurane with or without nitrous oxide at 0.83, 1.24, and 1.66 MAC
C
Comparator
Baseline values before stimulation (control)
O
Outcome
Cardiovascular responses (cardiac output, heart rate, systemic arterial blood pressure, central venous pressure, pulmonary arterial blood pressure, and systemic vascular resistance) at 0, 1, 2, 4, and 6 min after tetanic electrical stimulationsurrogate

Lower doses of desflurane (0.83 and 1.24 MAC) do not abolish cardiovascular responses to stimulation, but a higher dose (1.66 MAC) attenuates these responses.

Cite This Study

Yasuda et al. (1991) studied this question.

synapsesocial.com/papers/6a901985ed78fcc1e60d2d76https://doi.org/10.1213/00000539-199108000-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Actions of Desflurane in Normocarbic Volunteers1991 · 132 citations
  2. 2Cardiovascular effects of desflurane in experimental animals and volunteers1995 · 40 citations
  3. 3Cardiovascular Responses to Endotracheal Intubation in Patients Receiving Desflurane Anesthesia for Anesthetic Induction2004
  4. 4Desflurane Attenuates the Somatosympathetic Reflex in Rats1996 · 10 citations
  5. 5Administration of sufentanil and nitrous oxide blunts cardiovascular effects of desflurane but does not prevent an increase in middle cerebral artery blood flow velocity1997 · 5 citations