Why the study?
What are the cardiovascular effects of desflurane compared to other volatile anesthetics in experimental animals and humans?
Population
Experimental animals, volunteers, and patients undergoing coronary artery bypass graft surgery
Comparison
Desflurane vs Isoflurane and sevoflurane
Design
Review
Authors
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Supports blunting sympathetic surges with rapid desflurane rises in unstable patients; leaves open head-to-head trials versus other volatiles.
What are the cardiovascular effects of desflurane compared to other volatile anesthetics in experimental animals and humans?
Desflurane produces dose-dependent decreases in left ventricular function and vascular resistance, but rapid concentration increases can cause sympathetic activation that requires pharmacological blunting.
Richard B. Weiskopf (1995) studied this question.
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