Key result
1.5 MAC desflurane elicited a biphasic hemodynamic response and augmented norepinephrine release, with an initial peak within 2 minutes and a secondary peak at 3 to 5 minutes after endotracheal intubation.
Why the study?
Does desflurane alter cardiovascular and catecholamine responses to endotracheal intubation compared to sevoflurane in healthy adults?
RCT (n=75)
Randomized
Does desflurane alter cardiovascular and catecholamine responses to endotracheal intubation compared to sevoflurane in healthy adults?
High-dose (2 MAC) desflurane causes a biphasic hemodynamic response and augmented norepinephrine release following endotracheal intubation.
Answers are grounded in this paper and cite their sources.
Supports preferring sevoflurane for intubation stability in hemodynamically vulnerable patients; extends biphasic norepinephrine findings from 2 MAC to 1.5 MAC.
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Jeong et al. (2004) conducted an RCT in Patients undergoing anesthetic induction and endotracheal intubation (n=75). Desflurane vs. 1.0 MAC sevoflurane was evaluated on Cardiovascular responses (systolic arterial blood pressure and heart rate) and plasma catecholamine concentrations. 1.5 MAC desflurane elicited a biphasic hemodynamic response and augmented norepinephrine release, with an initial peak within 2 minutes and a secondary peak at 3 to 5 minutes after endotracheal intubation.
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