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August 1, 1991Anesthesia & Analgesia

Cardiovascular Actions of Desflurane in Normocarbic Volunteers

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Why the study?

Does desflurane alter cardiovascular hemodynamics in unmedicated normocapnic male volunteers?

Population

12 unmedicated normocapnic, normothermic male volunteers

Comparison

Desflurane at concentrations of 0.83, 1.24, and… vs Measurements obtained while the same men were…

Design

Other

Follow-up

7 hours

Authors

RWRichard B. WeiskopfCross-Cutting CardiologyMCMichael K. CahalanJikei University School of MedicineEEEdmond I. EgerUniversity of Central Florida

Discussion

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Implication

Volunteer data warrant no practice change; leaves open desflurane's net effects during clinical anesthesia.

Structured PICO

Does desflurane alter cardiovascular hemodynamics in unmedicated normocapnic male volunteers?

P
Population
12 unmedicated normocapnic, normothermic male volunteers
I
Intervention
Desflurane at concentrations of 0.83, 1.24, and 1.66 MAC, with controlled ventilation and constant PaCO2, for up to 7 hours
C
Comparator
Measurements obtained while the same men were conscious
O
Outcome
Cardiovascular hemodynamics including right-heart filling pressure, systemic vascular resistance, mean systemic arterial blood pressure, and echocardiographic measures (LVEDA, systolic wall stress, cardiac index, LVEF, heart rate, stroke volume index)surrogate

Desflurane causes dose-dependent cardiovascular depression with decreased systemic vascular resistance and stroke volume index, but cardiac output is maintained.

Cite This Study

Weiskopf et al. (1991) studied this question.

synapsesocial.com/papers/6a82bb6ffb68d755121c23cehttps://doi.org/10.1213/00000539-199108000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular effects of desflurane in experimental animals and volunteers1995 · 39 citations
  2. 2Cardiovascular Responses to Endotracheal Intubation in Patients Receiving Desflurane Anesthesia for Anesthetic Induction2004
  3. 3Does Desflurane Modify Circulatory Responses to Stimulation in Humans?1991 · 33 citations
  4. 4Cardiovascular effects of desflurane and isoflurane in patients with coronary artery disease1996 · 20 citations
  5. 5Cardiovascular Effects of Sevoflurane Compared with Those of Isoflurane in Volunteers1995 · 229 citations