Trend of Platelet Function in Arteriosclerotic Diseases by Multivariate Analysis

Platelet function was studied comparatively by means of multiple comparison (Scheffe), for which used, as an arteriosclerotic group, were cases of effort angina (33), myocardial infarction (32) and cerebral infarction (25), totalling 90, their ages averaging 65.8±10.1, as the internal samples, and 50 cases of normal healthy subjects group, their ages averaging 48.3±3.2, as controls. Next, relationship between the value of the platelet function test and the risk factor of individual patients which is presumed to exert influence on the former was studied by the multivariate analysis, and then an estimate formula for the value of platelet function test was prepared by the use of the risk factor. The formula was applied continually to total 30 cases of arteriosclerotic diseases, and the following results were obtained. As platelet function tests, platelet aggregation (Pl-Ag), thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-Keto-PGF1α), β-thromboglobulin (β-TG) and platelet factor 4 (PF4) were examined.1. All the diseases in the arteriosclerotic group except effort angina showed higher values of Pl-Ag, TXB2, β-TG, PF4 than those of the normal healthy subjects group, but no significant difference was observed in 6-Keto-PGF1α.2. Regarding mutual relationship between platelet function tests, good correlationships were observed between TXB2 and TXB2/6-Keto-PGF1α and between β-TG and PF4 both in the normal healthy subjects group and arteriosclerotic group.3. It was found that sex, age and blood pressure are important as the patients' background factors which exert i nfluence on the value of platelet function test.4. As a result of applying the estimate formula for the value of platelet function test obtained to the subsequent cases, relatively satisfactory results were obtained confirming the reasonability of the estimate formula.Thus, it was presumed that the correlation of risk factor of individual patients with arteriosclerotic diseases with platelet function alone is weak, but that total judgement of these test items by putting importance to them enables us to know platelet function almost correctly which is found to be of significance.