Population
Poliovirus polymerase (3Dpol) and viral RNA replication systems (cell-free and in vivo HeLa cells)
Comparison
Mutations at residue 5 of poliovirus polymerase vs Wild-type poliovirus polymerase
Design
Preclinical
Authors
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May guide antiviral design targeting polymerase stability; leaves open clinical translation pending human validation.
A large hydrophobic amino acid at residue 5 of the poliovirus polymerase is critical for maintaining the stability of the elongation complex during RNA replication.
Hobdey et al. (2010) studied this question.
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