Key result
Strict blood pressure control did not delay the onset of ESRD but significantly reduced the adjusted risk of all-cause mortality by 19% (HR 0.81) compared to usual blood pressure control in African Americans with chronic kidney disease.
Why the study?
Does strict blood pressure control reduce the long-term risk of ESRD and mortality in African Americans with chronic kidney disease?
Population
n=1,067 African American adults with chronic kidney disease, mean age ~54, ~61% male. Key inclusion: GFR…
Comparison
Strict blood pressure control vs Usual blood pressure control
Design
Cohort, Randomized to either strict or usual BP control; simultaneously…
Follow-up
median 14.4 years
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Strict BP targets should not yet change practice in African American CKD; leaves open a mortality benefit for randomized confirmation.
Cohort (n=1,067)
Randomized (in original trial)
Yes
Does strict blood pressure control reduce the long-term risk of ESRD and mortality in African Americans with chronic kidney disease?
Hazard Ratio: 0.81 (95% CI 0.68–0.98)
Absolute Event Rate: 3.42% vs 3.7%
p-value: p=0.03
Long-term follow-up of the AASK trial demonstrates that strict blood pressure control in chronic kidney disease does not delay the onset of ESRD but significantly reduces the relative risk of all-cause mortality.
A 2016 study conducted a cohort in Chronic kidney disease (n=1,067). Strict blood pressure control vs. Usual blood pressure control (Mean arterial pressure 102-107 mmHg) was evaluated on All-cause mortality (HR 0.81, 95% CI 0.68-0.98, p=0.03). Strict blood pressure control did not delay the onset of ESRD but significantly reduced the adjusted risk of all-cause mortality by 19% (HR 0.81) compared to usual blood pressure control in African Americans with chronic kidney disease.
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