Key result
Large volume paracentesis significantly decreased peripheral resistance by 29% (p<0.01), a haemodynamic change that was not reversed by subsequent albumin infusion.
Why the study?
Does albumin infusion reverse circulatory changes following large volume paracentesis in patients with liver cirrhosis and tense ascites?
Population
11 patients with portal hypertensive ascites secondary to liver cirrhosis of Child's class B or C
Comparison
Large volume paracentesis followed by albumin… vs Baseline (end of equilibration phase)
Design
Cohort
Follow-up
end of follow-up phase (short-term during procedure)
Authors
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Albumin fails to reverse paracentesis-induced resistance drop in cirrhosis; hypothesis-generating and should not yet change practice.
Observational (n=11)
Does albumin infusion reverse circulatory changes following large volume paracentesis in patients with liver cirrhosis and tense ascites?
Effect estimate: -29 ± 24%
p-value: p=< 0.01
Albumin infusion fails to restore the significant decrease in peripheral resistance induced by large volume paracentesis in patients with liver cirrhosis.
Schneditz et al. (2007) conducted an observational in Liver cirrhosis and tense ascites (n=11). Large volume paracentesis and albumin infusion vs. Baseline (end of equilibration phase) was evaluated on Change in peripheral resistance (-29 ± 24%, p=< 0.01). Large volume paracentesis significantly decreased peripheral resistance by 29% (p<0.01), a haemodynamic change that was not reversed by subsequent albumin infusion.
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