Key result
Large-volume paracentesis without colloid replacement in cirrhosis patients led to a progressive decline in creatinine clearance from 77 at baseline to 60 ml/min at 48 hours (p<0.05).
Why the study?
Does large-volume paracentesis without colloid replacement affect hemodynamics and renal function in patients with cirrhosis and tense ascites?
Observational (n=13)
Does large-volume paracentesis without colloid replacement affect hemodynamics and renal function in patients with cirrhosis and tense ascites?
Absolute Event Rate: 60% vs 77%
p-value: p=<0.05
Large-volume paracentesis without colloid replacement in cirrhotic patients with tense ascites has no immediate adverse cardiovascular effects but causes a progressive decline in renal function.
No takes yet. Share an insight, caveat, or question.
May warrant renal monitoring after unreplaced paracentesis; leaves open whether colloid replacement prevents decline in cirrhosis.
Simon et al. (1987) conducted an observational in Cirrhosis and tense ascites (n=13). Large-volume paracentesis without intravenous colloid replacement vs. Baseline was evaluated on Creatinine clearance at 48 hours (p=<0.05). Large-volume paracentesis without colloid replacement in cirrhosis patients led to a progressive decline in creatinine clearance from 77 at baseline to 60 ml/min at 48 hours (p<0.05).
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