Why the study?
Does 5 liter large volume paracentesis cause hypovolemia in patients with tense ascites and peripheral edema due to chronic liver disease?
Population
18 patients (20 paracenteses) with tense ascites and peripheral edema due to chronic liver disease
Design
Cohort
Follow-up
48 hours
Authors
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No significant plasma volume change after 5-L paracentesis; hypothesis-generating for safety in edematous ascites and requires randomized confirmation.
Does 5 liter large volume paracentesis cause hypovolemia in patients with tense ascites and peripheral edema due to chronic liver disease?
Large volume (5 liter) paracentesis appears safe and does not cause significant hypovolemia in patients with tense ascites and peripheral edema due to chronic liver disease.
Kao et al. (1985) studied this question.
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