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December 1, 1966CirculationOpen Access

Severe Pulsus Alternans Associated with Primary Myocardial Disease in Children

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Population

5 children with clinically similar primary myocardial disease and moderate-to-severe pulsus alternans.

Design

Case_series

Authors

LHLeonard C. HarrisTexas Medical CenterQNQuang X. NghiemThe University of Texas Medical Branch at GalvestonMSMelvyn H. SchreiberThe University of Texas Medical Branch at Galveston

Discussion

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Implication

Pulsus alternans in pediatric myocardial disease may reflect alternating preload and impaired contractility; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

P
Population
5 children (including 2 siblings) with clinically similar primary myocardial disease and moderate-to-severe pulsus alternans.
I
Intervention
Cardiac catheterization and pacing in the right atrium and right ventricle
O
Outcome
Hemodynamic characteristics of pulsus alternans (left ventricular volumes, pressures, and intervals)surrogate

In children with primary myocardial disease, pulsus alternans is associated with alternating end-diastolic volumes and pressures, suggesting impaired contractility as an etiological factor.

Cite This Study

Harris et al. (1966) studied this question.

synapsesocial.com/papers/6a90401fccd91641af4dce8fhttps://doi.org/10.1161/01.cir.34.6.948

Topics

Heart failureHFrEF treatmentCardiomyopathyCardiac amyloidosis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on Starling's Law of the Heart1962 · 105 citations
  2. 2STROKE VOLUME AND RELATED HEMODYNAMIC DATA IN NORMAL CHILDREN1964 · 27 citations
  3. 3Left ventricular ejection time index in man1963 · 155 citations
  4. 4Pulsus Alternans in Aortic Stenosis1958 · 36 citations
  5. 5Discordant Pulsus Alternans1960 · 11 citations