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October 1, 1982Acta Anaesthesiologica Scandinavica

Postoperative Analgesia and Lung Function: a Comparison of Intramuscular with Epidural Morphine

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Why the study?

Does epidural morphine improve postoperative lung function compared to intramuscular morphine in healthy patients undergoing cholecystectomy or duodenal ulcer operation?

Population

30 healthy patients subjected to cholecystectomy or operation for duodenal ulcer

Comparison

Epidural morphine, given on demand for… vs Intramuscular morphine, given on demand for…

Design

RCT, allocated randomly

Follow-up

postoperatively

Authors

LRL RybroAarhus University HospitalBSB. A. SchurizekAarhus University HospitalTPTom PetersenUniversity of Pittsburgh

Discussion

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Overview

Supports epidural over i.m. morphine to reduce postoperative pulmonary changes after upper abdominal surgery; reinforces regional analgesia benefits in RCTs.

Structured PICO

Does epidural morphine improve postoperative lung function compared to intramuscular morphine in healthy patients undergoing cholecystectomy or duodenal ulcer operation?

P
Population
30 healthy patients subjected to cholecystectomy or operation for duodenal ulcer
I
Intervention
Epidural morphine, given on demand for satisfactory pain relief
C
Comparator
Intramuscular (i.m.) morphine, given on demand for satisfactory pain relief
O
Outcome
Postoperative lung dysfunction (radiological changes in the lungs, arterial oxygen tension, and alveolar-arterial oxygen difference)surrogate

Epidural morphine reduces the degree of postoperative lung dysfunction compared with conventional intramuscular morphine treatment in patients undergoing upper abdominal surgery.

Cite This Study

Rybro et al. (1982) studied this question.

synapsesocial.com/papers/6a9042180691efebbb2785e7https://doi.org/10.1111/j.1399-6576.1982.tb01810.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary Complications, Ventilation and Blood Gases after Upper Abdominal Surgery1977 · 70 citations
  2. 2Epidural Narcotics for Postoperative Analgesia1981 · 337 citations
  3. 3Serum Levels Following Epidural Administration of Morphine and Correlation with Relief of Postsurgical Pain1981 · 82 citations
  4. 4The Effects of Postoperative Peridural Analgesia on Pulmonary Therapy and Pulmonary Complications1974 · 109 citations