Key result
An automated 384-well patch-clamp system successfully measured hERG channel inhibition by various blockers in mammalian cells, yielding IC50 values consistent with previous literature.
The automated 384-well patch-clamp system provides an efficient, high-throughput method for screening hERG channel inhibition to assess drug-induced proarrhythmic risk.
Authors
No takes yet. Share an insight, caveat, or question.
May facilitate high-throughput hERG screening in drug development; hypothesis-generating pending clinical correlation.
Haraguchi et al. (2015) studied this question. Automated 384-well patch-clamp system was evaluated on IC50 of hERG channel blockers. An automated 384-well patch-clamp system successfully measured hERG channel inhibition by various blockers in mammalian cells, yielding IC50 values consistent with previous literature.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: