February 1, 1999British Journal of PharmacologyOpen Access

Rate‐dependent blockade of a potassium current in human atrium by the antihistamine loratadine

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Why the study?

Does loratadine inhibit potassium currents in human atrial myocytes?

Population

Human atrial myocytes

Design

Preclinical

Authors

WCWilliam CrumbNova Research Company (United States)

Discussion

Member takes

Implication

May increase supraventricular arrhythmia risk via Ito inhibition; leaves open clinical relevance pending human studies.

Structured PICO

Does loratadine inhibit potassium currents in human atrial myocytes?

Population

Human atrial myocytes

Intervention

Loratadine (including 10 nM concentration)

Outcome

Effect on transient outward K current (Ito), sustained current (Isus), and current measured at -100 mV (IK1 and Ins)surrogate

Loratadine rate-dependently inhibits the transient outward potassium current in human atrial myocytes, providing a potential mechanism for associated supraventricular arrhythmias.

Cite This Study

William Crumb (1999) studied this question.

synapsesocial.com/papers/6a905101109970a0fe90a264 https://doi.org/10.1038/sj.bjp.0702273

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Ask AI

Bookmark

Rate‐dependent blockade of a potassium current in human atrium by the antihistamine loratadine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rate‐dependent blockade of a potassium current in human atrium by the antihistamine loratadine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider