Key result
Cardiac contractility modulation significantly reduced hibernating myocardium volume from 33% to 24% (P=0.04) and increased LVEF from 21% to 25% (P=0.01) at 6 months.
Why the study?
To evaluate changes in myocardial contractility, perfusion, and hibernating myocardium volume using SPECT during cardiac contractility modulation and optimal medical therapy in ischemic chronic heart failure.
Does cardiac contractility modulation improve myocardial contractility and reduce hibernating myocardium volume in patients with ischemic chronic heart failure?
Cohort (n=31)
Does cardiac contractility modulation improve myocardial contractility and reduce hibernating myocardium volume in patients with ischemic chronic heart failure?
Absolute Event Rate: 24% vs 33%
p-value: p=0.04
Cardiac contractility modulation improves LVEF and reduces the volume of hibernating myocardium in patients with ischemic chronic heart failure.
May suggest CCM reduces hibernating myocardium volume in ischemic HF; leaves open need for randomized trials before practice change.
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Amanatova et al. (2021) conducted a cohort in Chronic ischemic heart failure (n=31). Cardiac contractility modulation vs. Baseline was evaluated on Hibernating myocardium volume (p=0.04). Cardiac contractility modulation significantly reduced hibernating myocardium volume from 33% to 24% (P=0.04) and increased LVEF from 21% to 25% (P=0.01) at 6 months.
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