Population
In vitro models and cardiomyocytes
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether C-terminal residues drive human sarcomere assembly defects.
A cluster of four positive residues at the C-terminus of sarcomeric myosins is essential for proper myosin filament assembly and incorporation into the sarcomere.
Thompson et al. (2012) studied this question.
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