December 14, 2007Journal of Experimental BiologyOpen Access

TheDrosophilamuscle LIM protein, Mlp84B, is essential for cardiac function

View Full Paper

Ask AI

Bookmark

Population

Drosophila model

Design

Preclinical

Authors

AMAnnabelle MérySalk Institute for Biological Studies OTOuarda Taghli-LamallemCentre National de la Recherche Scientifique KCKathleen A. ClarkNational Institute for Occupational Safety and Health

Discussion

Member takes

Implication

Establishes Drosophila as a model for Z-disc cardiomyopathy; leaves open translation to human diastolic dysfunction.

Structured PICO

Population

Drosophila model

Intervention

Genetic ablation and cardiac-specific RNA interference (RNAi) knockdown of mlp84B

Outcome

Cardiac function (diastolic interval, heart rhythm, lifespan, structural phenotype)surrogate

Mlp84B is essential for normal cardiac function in Drosophila, establishing it as a model for studying cardiomyopathy related to defective Z-disc components.

Cite This Study

Méry et al. (2007) studied this question.

synapsesocial.com/papers/6a906446e8d327d500342b09 https://doi.org/10.1242/jeb.012435

View Full Paper

Ask AI

Bookmark

TheDrosophilamuscle LIM protein, Mlp84B, is essential for cardiac function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

TheDrosophilamuscle LIM protein, Mlp84B, is essential for cardiac function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider