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November 1, 1985Clinical CardiologyOpen Access

Hemodynamic and metabolic effects of enalapril in patients with heart failure

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Why the study?

Does enalapril improve hemodynamic and functional parameters in patients with congestive heart failure?

Population

14 patients with congestive heart failure (CHF), New York Heart Association class II-III

Comparison

Enalapril added to conventional treatment vs Placebo added to conventional treatment

Design

RCT, double-blind

Follow-up

14 weeks

Authors

SCS.G. ChrysantOklahoma City UniversitySGS GollubUniversity of Kansas Medical CenterMDMarvin DunnUniversity of Bahrain

Discussion

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Member takes

Overview

Supports adding enalapril to conventional HF therapy for hemodynamic and EF gains; reinforces ACE inhibitor benefits in this RCT.

Structured PICO

Does enalapril improve hemodynamic and functional parameters in patients with congestive heart failure?

P
Population
14 patients with congestive heart failure (CHF), New York Heart Association class II-III
I
Intervention
Enalapril added to conventional treatment
C
Comparator
Placebo added to conventional treatment
O
Outcome
Treadmill test, ejection fraction by nuclear scan, cardiothoracic ratio, and Yale Scale score at 14 weekssurrogate

Enalapril safely improves hemodynamics and ejection fraction when added to conventional therapy in patients with heart failure.

Limitations

  • limited observations (small sample size)

Cite This Study

Chrysant et al. (1985) studied this question.

synapsesocial.com/papers/6a90646ca9a6d70ff18a4fe5https://doi.org/10.1002/clc.4960081107

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic and clinical response to enalapril, a long-acting converting-enzyme inhibitor, in patients with congestive heart failure.1984 · 123 citations
  2. 2Acute and long-term response to an oral converting-enzyme inhibitor, captopril, in congestive heart failure.1980 · 258 citations
  3. 3Angiotensin converting enzyme inhibition in patients with congestive heart failure.1978 · 236 citations
  4. 4Proteinuria During Long-term Captopril Therapy1980 · 101 citations